Journal of Food Quality and Hazards Control
مجله کیفیت و کنترل مخاطرات مواد غذایی
J. Food Qual. Hazards Control
Medical Sciences
http://jfqhc.ssu.ac.ir
1
admin
2345-685X
2345-6825
8
10.29252/jfqhc
14
8888
13
en
jalali
1395
9
1
gregorian
2016
12
1
3
4
online
1
fulltext
en
Toxicological Effects of 30-Day Intake of Malathion on the Male Reproductive System of Wistar Rats
تخصصي
Special
Original article
Original article
<p style="text-align: justify;"><span style="font-family:times new roman;"><strong>Background:</strong> Malathion (MAL) is a choice insecticide in the stored grain in different countries. The aim of the present study is to evaluate toxicological effects of 30-day intake of MAL on the male reproductive system of Wistar rats.</span></p>
<p style="text-align: justify;"><span style="font-family:times new roman;"><strong>Methods:</strong> This research was ethically approved by the local authority at Faculty of Medicine, Monastir, Tunisia. Three MAL treated groups received 1 ml corn oil containing 1.3, 13.7, and 137 mg/kg body weight/day, respectively. Body and testes weights, testosterone, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) levels were measured. Histopathological sections were prepared from testes of animals and stained with hematoxylin and eosin and also Masson trichrome. Statistical analysis was done using SPSS for windows version 10.</span></p>
<p style="text-align: justify;"><span style="font-family:times new roman;"><strong>Results:</strong> A meaningful decrease (<em>p</em><0.05) in the testes weight of treatment groups was observed compared to the control animals. However, no significant difference (<em>p</em>>0.05) was found between body weight of control and treatment groups. All the three MAL-treated rats had significantly (<em>p</em><0.05) lower plasma FSH, LH, and testosterone levels than the control group. Some major histopathological changes were found in testes sections of treatment groups.</span></p>
<p style="text-align: justify;"><span style="font-family:times new roman;"><strong>Conclusion:</strong> Our study revealed that subchronic and relatively short time exposure of male Wistar rats to MAL can induce histopathological changes in testes and disturbance in sex hormones levels in a dose-dependent manner.</span></p>
Malathion, Testis, Rats, Toxicology
152
156
http://jfqhc.ssu.ac.ir/browse.php?a_code=A-10-1-135&slc_lang=en&sid=1
I.
Flehi-Slim