en تخصصي Special Original article Original article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><strong>Background: </strong>Oily fish and their extracted oils may be a source of polychlorinated biphenyls (PCBs) which can induce toxic effects on the consumers. The main aim of this survey was estimation of PCBs intake through fish oil-derived dietary supplements and prescription drugs in the Japanese population.<br> <strong>Methods:</strong> PCBs levels were determined in 20 fish oil-derived dietary supplements and 6 oil-derived prescription drugs from the Japanese market using Gas Chromatography-Mass Spectrometry. Then, the daily exposure to PCBs was estimated. Data were statistically analyzed using JMP software suite.<br> <strong>Results:</strong> Totally, 17 of the 26 fish oil-derived products were contaminated with PCBs. The median PCB concentrations in the total set of fish oil-derived products was 2.2 ng/g oil wt. with a range of <MDL-720 ng/g oil wt. The average total daily intake of PCBs was estimated to be ranged from 770 to 2800 ng/day in the Japanese population.<br> <strong>Conclusion:</strong> PCBs intakes through fish oil-derived dietary supplements and prescription drugs in the Japanese adults were much lower than tolerable daily intake.<br> <br> <strong>DOI:</strong> 10.18502/jfqhc.6.4.1992</span></span></div> Polychlorinated Biphenyls, Fish Oils, Dietary Supplements, Prescription Drugs, Risk Assessment, Japan 146 152 http://jfqhc.ssu.ac.ir/browse.php?a_code=A-10-834-2&slc_lang=en&sid=1 Y. Matsuo No Graduate School of Agriculture, Saga University, Saga, Japan K. Nakai No Department of Development and Environmental Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan I. Sakuma No Caress Sapporo Hokko Memorial Clinic, Sapporo, Japan K. Akutsu No Food Chemistry Section 1, Division of Hygienic Chemistry, Osaka Institute of Public Health, Osaka, Japan N. Tatsuta No Department of Development and Environmental Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan M. Ishiyama No Graduate School of Agriculture, Saga University, Saga, Japan T. Higuchi No Graduate School of Agriculture, Saga University, Saga, Japan N. Ryuda No Graduate School of Agriculture, Saga University, Saga, Japan D. Ueno uenod@cc.saga-u.ac.jp 0000-0002-2022-1420 Yes Graduate School of Agriculture, Saga University, Saga, Japan