Volume 6, Issue 4 (December 2019)                   J. Food Qual. Hazards Control 2019, 6(4): 146-152 | Back to browse issues page


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Matsuo Y, Nakai K, Sakuma I, Akutsu K, Tatsuta N, Ishiyama M, et al . Estimation of Polychlorinated Biphenyls Intake through Fish Oil-Derived Dietary Supplements and Prescription Drugs in the Japanese Population. J. Food Qual. Hazards Control. 2019; 6 (4) :146-152
URL: http://jfqhc.ssu.ac.ir/article-1-631-en.html
Graduate School of Agriculture, Saga University, Saga, Japan , uenod@cc.saga-u.ac.jp
Abstract:   (272 Views)
Background: Oily fish and their extracted oils may be a source of polychlorinated biphenyls (PCBs) which can induce toxic effects on the consumers. The main aim of this survey was estimation of PCBs intake through fish oil-derived dietary supplements and prescription drugs in the Japanese population.
Methods: PCBs levels were determined in 20 fish oil-derived dietary supplements and 6 oil-derived prescription drugs from the Japanese market using Gas Chromatography-Mass Spectrometry. Then, the daily exposure to PCBs was estimated. Data were statistically analyzed using JMP software suite.
Results: Totally, 17 of the 26 fish oil-derived products were contaminated with PCBs. The median PCB concentrations in the total set of fish oil-derived products was 2.2 ng/g oil wt. with a range of <MDL-720 ng/g oil wt. The average total daily intake of PCBs was estimated to be ranged from 770 to 2800 ng/day in the Japanese population.
Conclusion: PCBs intakes through fish oil-derived dietary supplements and prescription drugs in the Japanese adults were much lower than tolerable daily intake.

DOI: 10.18502/jfqhc.6.4.1992
Full-Text [PDF 482 kb]   (78 Downloads)    
Type of Study: Original article | Subject: Special
Received: 19/07/01 | Accepted: 19/11/15 | Published: 19/12/16

References
1. Akutsu K., Tanaka Y., Hayakawa K. (2006). Occurrence of polybrominated diphenyl ethers and polychlorinated biphenyls in shark liver oil supplements. Food Additives and Contaminants. 23: 1323-1329. [DOI: 10.1080/ 02652030600892966] [DOI:10.1080/02652030600892966] [PMID]
2. Al-Ghannami S.S., Al-Adawi S., Ghebremeskel K., Hussein I.S., Min Y., Jeyaseelan L., Al-Shammakhi S.M., Mabry R.M., Al-Oufi H.S. (2019). Randomized open-label trial of docosahexaenoic acid-enriched fish oil and fish meal on cognitive and behavioral functioning in Omani children. Nutrition. 57: 167-172. [DOI: 10.1016/j.nut.2018.04.008] [DOI:10.1016/j.nut.2018.04.008] [PMID]
3. Aylward L.L., Hays S.M., Kirman C.R., Marchitti S.A., Kenneke J.F., English C., Mattison D.R., Becker R.A. (2014). Relationships of chemical concentrations in maternal and cord blood: a review of available data. Journal of Toxicology and Environmental Health-Part B: Critical Reviews. 17: 175-203. [DOI: 10.1080/10937404.2014.884956] [DOI:10.1080/10937404.2014.884956] [PMID]
4. Borgå K., Fisk A.T., Hoekstra P.F., Muir D.C.G. (2004). Biological and chemical factors of importance in the bioaccumulation and trophic transfer of persistent organochlorine contaminants in arctic marine food webs. Environmental Toxicology and Chemistry. 23: 2367-2385. [DOI: 10.1897/03-518] [DOI:10.1897/03-518] [PMID]
5. Bourdon J.A., Bazinet T.M., Arnason T.T., Kimpe L.E., Blais J.M., White P.A. (2010). Polychlorinated biphenyls (PCBs) contamination and aryl hydrocarbon receptor (AhR) agonist activity of Omega-3 polyunsaturated fatty acid supplements: implications for daily intake of dioxins and PCBs. Food and Chemical Toxicology. 48: 3093-3097. [DOI: 10.1016/j.fct. 2010.07.051] [DOI:10.1016/j.fct.2010.07.051] [PMID]
6. Breslow J.L. (2006). n-3 Fatty acids and cardiovascular disease. The American Journal of Clinical Nutrition. 83: 1477S-1482S. [DOI: 10.1093/ajcn/83.6.1477S] [DOI:10.1093/ajcn/83.6.1477S] [PMID]
7. Dwyer J.T., Coates P.M., Smith M.J. (2018). Dietary supplements: regulatory challenges and research resources. Nutrients. 10: 41. [DOI: 10.3390/nu10010041] [DOI:10.3390/nu10010041] [PMID] [PMCID]
8. Dwyer J., Nahin R.L., Rogers G.T., Barnes P.M., Jacques P.M., Sempos C.T., Bailey R. (2013). Prevalence and predictors of children's dietary supplement use: the 2007 National Health Interview Survey. The American Journal of Clinical Nutrition. 97: 1331-1337. [DOI: 10.3945/ajcn.112.052373] [DOI:10.3945/ajcn.112.052373] [PMID] [PMCID]
9. Faroon O.M., Keith S.L., De Rosa C., Christopher T., World Health Organization et al. (2003). Polychlorinated biphenyls: human health aspects. World Health Organization. Concise International Chemical Assessment Document 55. Geneva, Swizerland. URL: https://apps.who.int/iris/handle/10665/ 42640. Accessed 1 May 2019.
10. Fernandes A.R., Rose M., White S., Mortimer D.N., Gem M. (2006). Dioxins and polychlorinated biphenyls (PCBs) in fish oil dietary supplements: occurrence and human exposure in the UK. Food Additives and Contaminants. 23: 939-947. [DOI: 10.1080/02652030600660827] [DOI:10.1080/02652030600660827] [PMID]
11. Godwin M., Crellin J., Mathews M., Chowdhury N.L., Newhook L.A., Pike A., McCrate F., Law R. (2013). Use of natural health products in children: survey of parents in waiting rooms. Canadian Family Physician. 59: 364-371.
12. Green N.W., Knutzen J. (2003). Organohalogens and metals in marine fish and mussels and some relationships to biological variables at reference localities in Norway. Marine Pollution Bulletin. 46: 362-374. [DOI: 10.1016/S0025-326X(02)00515-5] [DOI:10.1016/S0025-326X(02)00515-5]
13. Greger J.L. (2001). Dietary supplement use: consumer characteristics and interests. The Journal of Nutrition. 131: 1339S-1343S. [DOI: 10.1093/jn/131.4.1339S] [DOI:10.1093/jn/131.4.1339S] [PMID]
14. Haque R., Inaoka T., Fujimura M., Ahmad A.S., Ueno D. (2017). Intake of DDT and its metabolites through food items among reproductive age women in Bangladesh. Chemosphere. 189: 744-751. [DOI: 10.1016/j.chemosphere.2017.09.041] [DOI:10.1016/j.chemosphere.2017.09.041] [PMID]
15. Huybrechts I., Maes L., Vereecken C., De Keyzer W., De Bacquer D., De Backer G., De Henauw S. (2010). High dietary supplement intakes among Flemish preschoolers. Appetite. 54: 340-345. [DOI: 10.1016/j.appet.2009.12.012] [DOI:10.1016/j.appet.2009.12.012] [PMID]
16. Jacobs M.N., Covaci A., Gheorghe A., Schepens P. (2004). Time trend investigation of PCBs, PBDEs, and organochlorine pesticides in selected n-3 polyunsaturated fatty acid rich dietary fish oil and vegetable oil supplements; nutritional relevance for human essential n-3 fatty acid requirements. Journal of Agricultural and Food Chemistry. 52: 1780-1788. [DOI: 10.1021/jf035310q] [DOI:10.1021/jf035310q] [PMID]
17. Jacobson J.L., Jacobson S.W., Humphrey H.E.B. (1990). Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. The Journal of Pediatrics. 116: 38-45. [DOI: 10.1016/S0022-3476(05)81642-7] [DOI:10.1016/S0022-3476(05)81642-7]
18. Kuratko C.N., Barrett E.C., Nelson E.B., Salem Jr N. (2013). The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. Nutrients. 5: 2777-2810. [DOI: 10.3390/nu5072777] [DOI:10.3390/nu5072777] [PMID] [PMCID]
19. Martí M., Ortiz X., Gasser M., Martí R., Montaña M.J., Díaz-Ferrero J. (2010). Persistent organic pollutants (PCDD/Fs, dioxin-like PCBs, marker PCBs, and PBDEs) in health supplements on the Spanish market. Chemosphere. 78: 1256-1262. [DOI: 10.1016/j.chemosphere.2009.12.038] [DOI:10.1016/j.chemosphere.2009.12.038] [PMID]
20. Mason P. (2000). Fish oils-an update. The Pharmaceutical Journal. 265: 720-724.
21. Ministry of Health Labour and Welfare of Japan. (2011). The national health and nutrition survey Japan [in Japanese]. URL: https://www.mhlw.go.jp/bunya/kenkou/eiyou/h23-houkoku.html. Accessed 1 May 2019.
22. Mori T.A., Woodman R.J. (2006). The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. Current Opinion in Clinical Nutrition and Metabolic Care. 9: 95-104. [DOI: 10.1097/01.mco.0000214566.67439.58] [DOI:10.1097/01.mco.0000214566.67439.58] [PMID]
23. Mozaffarian D., Wu J.H.Y. (2011). Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. Journal of the American College of Cardiology. 58: 2047-2067. [DOI: 10.1016/j.jacc. 2011.06.063] [DOI:10.1016/j.jacc.2011.06.063] [PMID]
24. Nakai K., Suzuki K., Oka T., Murata K., Sakamoto M., Okamura K., Hosokawa T., Sakai T., Nakamura T., Saito Y., Kurokawa N., Kameo S., Satoh H. (2004). The Tohoku study of child development: a cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children. The Tohoku Journal of Experimental Medicine. 202: 227-237. [DOI: 10.1620/tjem.202.227] [DOI:10.1620/tjem.202.227] [PMID]
25. Neugebauer J., Wittsiepe J., Kasper-Sonnenberg M., Schöneck N., Schölmerich A., Wilhelm M. (2015). The influence of low level pre-and perinatal exposure to PCDD/Fs, PCBs, and lead on attention performance and attention-related behavior among German school-aged children: results from the Duisburg birth cohort study. International Journal of Hygiene and Environmental Health. 218: 153-162. [DOI: 10.1016/j. ijheh.2014.09.005] [DOI:10.1016/j.ijheh.2014.09.005] [PMID]
26. Parera J., Ábalos M., Santos F.J., Galceran M.T., Abad E. (2013). Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, paraffins and polybrominated diphenyl ethers in marine fish species from Ebro River Delta (Spain). Chemosphere. 93: 499-505. [DOI: 10.1016/j.chemosphere.2013.06.022] [DOI:10.1016/j.chemosphere.2013.06.022] [PMID]
27. Raine A., Portnoy J., Liu J., Mahoomed T., Hibbeln J.R. (2015). Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. The Journal of Child Psychology and Psychiatry. 56: 509-520. [DOI: 10.1111/jcpp.12314] [DOI:10.1111/jcpp.12314] [PMID] [PMCID]
28. Schmitz P.G., Antony K.A. (2002). ω-3 fatty acids in ESRD: should patients with ESRD eat more fish? Nephrology Dialysis Transplantation. 17: 11-14. [DOI: 10.1093/ndt/17.1.11] [DOI:10.1093/ndt/17.1.11] [PMID]
29. Shim S.M., Santerre C.R., Burgess J.R., Deardorff D.C. (2003). Omega-3 fatty acids and total polychlorinated biphenyls in 26 dietary supplements. Journal of Food Science. 68: 2436-2440. [DOI: 10.1111/j.1365-2621.2003.tb07042.x] [DOI:10.1111/j.1365-2621.2003.tb07042.x]
30. Stanton C., Gardiner G., Meehan H., Collins K., Fitzgerald G., Lynch P.B., Ross R.P. (2001). Market potential for probiotics. The American Journal of Clinical Nutrition. 73: 476S-483S. [DOI: 10.1093/ajcn/73.2.476s] [DOI:10.1093/ajcn/73.2.476s] [PMID]
31. Stewart P., Reihman J., Lonky E., Darvill T., Pagano J. (2000). Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicology and Teratology. 22: 21-29. [DOI: 10.1016/S0892-0362(99)00056-2] [DOI:10.1016/S0892-0362(99)00056-2]
32. Stewart P.W., Sargent D.M., Reihman J., Gump B.B., Lonky E., Darvill T., Hicks H., Pagano J. (2006). Response inhibition during differential reinforcement of low rates (DRL) schedules may be sensitive to low-level polychlorinated biphenyl, methylmercury, and lead exposure in children. Environmental Health Perspectives. 114: 1923-1929. [DOI: 10.1289/ehp.9216] [DOI:10.1289/ehp.9216] [PMID] [PMCID]
33. Stonehouse W. (2014). Does consumption of LC omega-3 PUFA enhance cognitive performance in healthy school-aged children and throughout adulthood? Evidence from clinical trials. Nutrients. 6: 2730-2758. [DOI: 10.3390/nu6072730] [DOI:10.3390/nu6072730] [PMID] [PMCID]
34. Storelli M.M., Storelli A., Marcotrigiano G.O. (2004). Polychlorinated biphenyls, hexachlorobenzene, hexachlorocy-clohexane isomers, and pesticide organochlorine residues in cod-liver oil dietary supplements. Journal of Food Protectection. 67: 1787-1791. [DOI: 10.4315/0362-028X-67.8.1787] [DOI:10.4315/0362-028X-67.8.1787] [PMID]
35. Storelli M.M., Storelli A., Marcotrigiano G.O. (2005). Concentrations and hazard assessment of polychlorinated biphenyls and organochlorine pesticides in shark liver from the Mediterranean Sea. Marine Pollution Bulletin. 50: 850-855. [DOI: 10.1016/j.marpolbul.2005.02.023] [DOI:10.1016/j.marpolbul.2005.02.023] [PMID]
36. Su G., Liu X., Gao Z., Xian Q., Feng J., Zhang X., Giesy J.P., Wei S., Liu H., Yu H. (2012). Dietary intake of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) from fish and meat by residents of Nanjing, China. Environment International. 42: 138-143. [DOI: 10.1016/j. envint.2011.05.015] [DOI:10.1016/j.envint.2011.05.015] [PMID]
37. Tatsuta N., Nakai K., Murata K., Suzuki K., Iwai-Shimada M., Kurokawa N., Hosokawa T., Satoh H. (2014). Impacts of prenatal exposures to polychlorinated biphenyls, methylmercury, and lead on intellectual ability of 42-month-old children in Japan. Environmental Research. 133: 321-326. [DOI: 10.1016/j.envres.2014.05.024] [DOI:10.1016/j.envres.2014.05.024] [PMID]
38. The United Nations Environment Programme (UNEP). (2017). General technical guidelines on the environmentally sound management of wastes consisting of containing or contaminated with persistent organic pollutants. URL: http://wwwbaselint/Implementation/Publications/ArchivedTechnicalGuidelines/tabid/2362/Defaultasp. Accessed 1 May 2019.
39. Tokyo Metropolitan Government. (2011). Estimation of intake of chemical substances from dietary [in Japanese]. URL: http://www.fukushihoken.metro.tokyo.jp/kankyo/kankyo_eisei/kagakutaisaku/shokuhin/kekka.html. Accessed 1 May 2019.
40. Ueno D., Takahashi S., Tanaka H., Subramanian A.N., Fillmann G., Nakata H., Lam P.K.S., Zheng J., Muchtar M., Prudente M., Chung K.H., Tanabe S. (2003). Global pollution monitoring of PCBs and organochlorine pesticides using skipjack tuna as a bioindicator. Archives of Environmental Contamination and Toxicology. 45: 378-389. [DOI: 10.1007/s00244-002-0131-9] [DOI:10.1007/s00244-002-0131-9] [PMID]
41. Vreugdenhil H.J.I., Lanting C.I., Mulder P.G.H., Boersma E.R., Weisglas-Kuperus N. (2002). Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age. The Journal of Pediatrics. 140: 48-56. [DOI: 10.1067/mpd.2002.119625] [DOI:10.1067/mpd.2002.119625] [PMID]
42. Weisglas-Kuperus N., Patandin S., Berbers G.A.M., Sas T.C.J., Mulder P.G.H., Sauer P.J.J., Hooijkaas H. (2000). Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environmental Health Perspectives. 108: 1203-1207. [DOI: 10.1289/ehp.001081203] [DOI:10.1289/ehp.001081203] [PMID] [PMCID]
43. Yazawa K. (1994). Docosahexaenoic acid (DHA). Journal of Synthetic Organic Chemistry Japan. 52: 1089-1090. [In Japanese]. [DOI: 10.5059/yukigoseikyokaishi.52.1089] [DOI:10.5059/yukigoseikyokaishi.52.1089]

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